Ryan Dorton Selected Research

EC145

12/2018	Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic.
1/2016	High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide.
4/2014	Rational combination therapy of vintafolide (EC145) with commonly used chemotherapeutic drugs.
3/2014	Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship.
2/2011	Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications.
9/2009	In vivo structural activity and optimization studies of folate-tubulysin conjugates.
5/2007	Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate.

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Ryan Dorton Research Topics

Disease

12	Neoplasms (Cancer) 01/2019 - 05/2007
2	Weight Loss (Weight Reduction) 01/2019 - 05/2007
1	Prostatic Neoplasms (Prostate Cancer) 01/2019
1	Lung Neoplasms (Lung Cancer) 01/2016
1	Constipation 02/2011
1	Lymphoma (Lymphomas) 05/2007

Drug/Important Bio-Agent (IBA)

10	Folic Acid (Vitamin M)FDA LinkGeneric 12/2018 - 05/2007
7	Pharmaceutical PreparationsIBA 01/2019 - 09/2007
7	EC145IBA 12/2018 - 05/2007
4	tubulysin BIBA 01/2019 - 12/2008
4	AlkaloidsIBA 12/2018 - 02/2011
3	EC0305IBA 06/2017 - 12/2008
2	Biological ProductsIBA 01/2019 - 09/2007
2	LigandsIBA 12/2008 - 09/2007
1	Docetaxel (Taxotere)FDA Link 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	AntigensIBA 01/2019
1	Paclitaxel (Taxol)FDA LinkGeneric 12/2018
1	Cisplatin (Platino)FDA LinkGeneric 12/2018
1	EC0531IBA 06/2017
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2016
1	HydrazinesIBA 01/2016
1	EC 0489IBA 02/2011
1	EC0225IBA 09/2007

Therapy/Procedure

5	Therapeutics 01/2019 - 03/2014